alleryStart learning →Live, attenuated vaccines carry which storage and handling requirement?
AThey must be mixed with an adjuvant first
BThey must be given with immune globulin
CThey must be protected from heat and light
DThey must be frozen before every single dose
Answer & Solution
Correct answer: C. They must be protected from heat and light
1. A live vaccine works only if the weakened organism is still alive and able to replicate.
2. Heat and light damage or destroy that organism, so these vaccines are fragile.
3. They must therefore be stored and handled carefully, protected from both heat and light.
4. Immune globulin would interfere with the vaccine rather than accompany it, so giving the two together is the opposite of good practice.
5. Adjuvants are added to improve the immunogenicity of other vaccines and are not a handling rule for live ones.
_Source: CDC Epidemiology and Prevention of Vaccine-Preventable Diseases (Pink Book), section Live, Attenuated Vaccines_
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