Which statement holds for inactivated vaccines?

1. Inactivated vaccines contain no live organism and cannot replicate in the body. 2. Without replication there is no infection, so they cannot cause disease even in someone whose immunity is impaired. 3. Inactivated antigens are less affected by circulating antibody than live antigens, so the third option is the wrong way round. 4. One dose usually primes rather than protects, so protection after a single dose describes injected live vaccines instead. 5. The response to an inactivated vaccine is mostly antibody with little cellular immunity, so the fourth option is also reversed. _Source: CDC Epidemiology and Prevention of Vaccine-Preventable Diseases (Pink Book), section Inactivated Vaccines_