alleryStart learning →Why must a live, attenuated vaccine replicate inside the person who receives it?
ATo keep the vaccine stable during storage
BTo produce an immune response at all
CTo prevent reversion to the wild form
DTo avoid interference by antibody
Answer & Solution
Correct answer: B. To produce an immune response at all
1. A live vaccine carries a weakened organism derived from a wild virus or bacterium.
2. Only a small dose is given, too small on its own to stimulate the immune system.
3. That dose must replicate in the body to create enough organism to raise an immune response.
4. Replication is also why circulating antibody, which blocks it, can cause the vaccine to fail.
_Source: CDC Epidemiology and Prevention of Vaccine-Preventable Diseases (Pink Book), section Live, Attenuated Vaccines_
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