alleryCisplatin, $[Pt(NH_3)_2Cl_2]$, is a **square planar** complex used as an anticancer drug. The trans-isomer:
AHas the same anticancer activity
BIs physiologically inactive
CIs more potent
DCannot exist for square planar geometry
Answer & Solution
Correct answer: B. Is physiologically inactive
Only the **cis** isomer is biologically active (binds adjacent N₇ of two guanine bases in DNA).
trans-Pt(NH₃)₂Cl₂ is inactive.
Geometry isomerism matters enormously for drug action.
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