Chief cells, located primarily in the basal regions of the gastric glands, secrete which inactive proenzyme?
APepsinogen
BGastrin
CHydrochloric acid
DIntrinsic factor
Answer & Solution
Correct answer: A. Pepsinogen
1. Chief cells are one of the four main secretory cell types in the gastric glands.
2. Located primarily in the basal regions of the glands, chief cells secrete pepsinogen, the inactive proenzyme form of pepsin.
3. HCl, produced separately by parietal cells, is necessary to convert this pepsinogen into active pepsin.
4. Gastrin is secreted by enteroendocrine G cells, while HCl and intrinsic factor are secreted by parietal cells, none of which is the specific proenzyme chief cells release.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 23 "The Digestive System", section 23.4, p. 1109_
Keep practising The Digestive System
Browse all The Digestive System questions for MBBS, or explore more Physiology topics.
Related questions
Place each milestone on the digestion timelineSpell the digestive termSpot the wrong wordFlip to match hormone and actionWhich stomach secretion, though small in overall digestive contribution, is described as tThe majority of peptic ulcers are caused by excessive intake of NSAIDs or by which infectiWhich stomach hormone is produced mainly in the fundus and regulates food intake by stimulGastrin is released mainly by enteroendocrine G cells located in which region of the stoma