Which type of stomach gland cell produces both hydrochloric acid and intrinsic factor?
AChief cells
BMucous neck cells
CEnteroendocrine cells
DParietal cells
Answer & Solution
Correct answer: D. Parietal cells
1. The gastric glands of the fundus and body of the stomach contain several distinct secretory cell types.
2. Parietal cells, located primarily in the middle region of the gastric glands, are large, highly differentiated cells.
3. These parietal cells produce both hydrochloric acid (HCl), responsible for gastric acidity, and intrinsic factor, needed for vitamin B12 absorption.
4. Chief cells instead secrete pepsinogen, mucous neck cells secrete acidic mucus, and enteroendocrine cells secrete hormones like gastrin, none of which produces both HCl and intrinsic factor.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 23 "The Digestive System", section 23.4, p. 1109_
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