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In Lowe disease, the deficient enzyme normally sits in which organelle?

AInside the lysosome
BInside the peroxisome
CInside the Golgi apparatus
DInside the mitochondrion
Answer & Solution
Correct answer: C. Inside the Golgi apparatus
1. Many diseases arise from genetic mutations that prevent the synthesis of critical proteins. 2. Lowe disease is one such disease, and it is also called oculocerebrorenal syndrome. 3. In it there is a deficiency in an enzyme localized to the Golgi apparatus. 4. Children born with it have cataracts and typically develop kidney disease after the first year of life. 5. The affected organelle is the Golgi apparatus. _Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 4 "Cell Structure", section 4.4 The Endomembrane System and Proteins_
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