A desmosome is built from cadherins linked to which cytoskeletal element?
AIntermediate filaments
BMicrofilaments of actin
CMicrotubules of tubulin
DConnexons of connexin
Answer & Solution
Correct answer: A. Intermediate filaments
1. Desmosomes are found only in animal cells and act like spot welds between adjacent epithelial cells.
2. Short proteins called cadherins sit in the plasma membrane.
3. Those cadherins connect to intermediate filaments, and that linkage creates the desmosome.
4. Intermediate filaments are the right partner because their function is purely structural, bearing tension.
5. Actin microfilaments are associated with movement rather than with this anchoring role.
6. Connexons build the pore of a gap junction, so they belong to a different junction entirely.
7. The linked element is the intermediate filament.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 4 "Cell Structure", section 4.6 Connections between Cells and Cellular Activities_
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