If a cell grows too large, which limitation arises?

1. Every molecule entering or leaving the cell must cross the plasma membrane. 2. The rate at which material can cross depends on how much membrane area is available. 3. The demand for that traffic depends on the volume of cytoplasm being served. 4. Because volume outgrows surface area, a large cell has too little membrane for the traffic its interior needs. 5. The plasma membrane then cannot support the rate of diffusion required for the increased volume. 6. DNA copying, water content and ribosome function are not what the geometry limits, so those three answers name the wrong bottleneck. 7. The limitation is that the membrane cannot support the required diffusion. _Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 4 "Cell Structure", section 4.2 Prokaryotic Cells_