If a DNA strand reads AATTGCGC, what is the sequence of the complementary RNA?
ATTAACGCG
BUUAACGCG
CAAUUGCGC
DUUAAGCGC
Answer & Solution
Correct answer: B. UUAACGCG
1. The RNA base sequence is complementary to the coding sequence of the DNA it is copied from.
2. Apply the pairing rules base by base to AATTGCGC.
3. In RNA the base thymine is absent and uracil is present instead, so each A in the DNA gives a U.
4. The first two A bases therefore give UU, and the next two T bases give AA.
5. G gives C and C gives G, so GCGC gives CGCG.
6. Putting the pieces together gives UUAACGCG.
7. The option reading TTAACGCG applies the DNA rule and forgets that RNA never carries thymine.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 3 "Biological Macromolecules", section 3.5 Nucleic Acids_
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