Home › NEET UG › Biology › Human Health and Disease ›  The toxic substance responsible for the chills and high fever of malaria is:
AHaemoglobin
BBilirubin
CHaemozoin — released when RBCs rupture
DInsulin
Answer & Solution
Correct answer: C. Haemozoin — released when RBCs rupture
When parasites rupture the RBCs, they release **haemozoin** (a toxic by-product of haemoglobin digestion). This triggers the **periodic chills and high fever every 3–4 days** characteristic of malaria.
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