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In Griffith's experiment (1928) on Streptococcus pneumoniae, which combination killed the mice?
AHeat-killed S strain + live R strain (R was transformed into virulent S)
BLive R strain only
CHeat-killed S strain only
DLive S strain mixed with live R strain
Answer & Solution
Correct answer: A. Heat-killed S strain + live R strain (R was transformed into virulent S)
Griffith's classic experiment: heat-killed S + live R → mice DIE. The R strain was 'transformed' into virulent S by some heat-stable 'transforming principle' from the dead S cells. Avery-MacLeod-McCarty later identified this principle as **DNA**.
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