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In the Watson-Crick model, the two polynucleotide strands of DNA are:

APerpendicular
BAnti-parallel (one 5′→3′, the other 3′→5′)
CParallel (both 5′→3′ in the same direction)
DRandom in orientation
Answer & Solution
Correct answer: B. Anti-parallel (one 5′→3′, the other 3′→5′)
**Anti-parallel** strands: one runs 5′→3′, the other 3′→5′. This is essential for base pairing and for the directionality of replication.
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