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The first MAJOR recombinant DNA pharmaceutical, released commercially in 1982, was:

ARecombinant human growth hormone
BHepatitis B vaccine (recombinant)
CErythropoietin (kidney patients)
DRecombinant human insulin (Humulin)
Answer & Solution
Correct answer: D. Recombinant human insulin (Humulin)
HUMULIN (Eli Lilly, 1982) was the first commercial rDNA drug: human insulin produced by genetically modified E. coli. Before that, insulin came from animal pancreases. Hepatitis B recombinant vaccine came later (1986).
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