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In a polynucleotide chain, two nucleotides are joined by which linkage, and at which carbon atoms of the sugar?

A{'text': "2'-5' phosphodiester linkage", 'label': 'A'}
B{'text': "1'-3' glycosidic linkage", 'label': 'B'}
C{'text': "5'-5' phosphoanhydride linkage", 'label': 'C'}
D{'text': "3'-5' phosphodiester linkage", 'label': 'D'}
Answer & Solution
Correct answer: D. {'text': "3'-5' phosphodiester linkage", 'label': 'D'}
Adjacent nucleotides are linked by a 3'-5' phosphodiester bond, joining the 3'-OH of one sugar to the 5'-phosphate of the next. The chain therefore has distinct 5' and 3' ends.
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