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Sickle-cell anemia is caused by a point mutation in the beta-globin gene that substitutes:
A{'text': 'Glutamate for valine', 'label': 'A'}
B{'text': 'Lysine for arginine', 'label': 'B'}
C{'text': 'Methionine for valine', 'label': 'C'}
D{'text': 'Valine for glutamate', 'label': 'D'}
Answer & Solution
Correct answer: D. {'text': 'Valine for glutamate', 'label': 'D'}
A single base change in the beta-globin gene replaces glutamate (Glu) with valine (Val) at position 6, producing HbS. This is the classic missense point mutation in NCERT.
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