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Passage: 'Patients who take aspirin daily for two years have a 25 per cent lower risk of heart attack than those who do not. Therefore, every middle-aged adult should be advised to take aspirin daily for cardiovascular health.' Which, if TRUE, MOST weakens the recommendation?

AAspirin is inexpensive
BThe studies were conducted in Europe
CAspirin has been in use for over a century
DDaily aspirin significantly increases the risk of major bleeding, including stroke, in many middle-aged adults — possibly outweighing the cardiovascular benefit
Answer & Solution
Correct answer: D. Daily aspirin significantly increases the risk of major bleeding, including stroke, in many middle-aged adults — possibly outweighing the cardiovascular benefit
Even where a benefit exists, an aggregate-risk recommendation requires weighing harms. The option supplies a serious counter-balancing harm (bleeding/stroke) that recasts the cost-benefit calculation.
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