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Sickle cell disease arises from a change in hemoglobin at:
AA single amino acid out of about 600
BAbout sixty amino acids out of six hundred
CA single amino acid out of about sixty
DAbout six amino acids out of about sixty
Answer & Solution
Correct answer: A. A single amino acid out of about 600
1. Hemoglobin is a large protein whose chains total roughly 600 amino acids.
2. The structural difference between normal hemoglobin and the sickle cell form is a single amino acid of the 600.
3. In normal hemoglobin the amino acid at position seven is glutamate; the substitution changes it.
4. That one change makes hemoglobin form long fibers that distort red blood cells into a crescent shape and clog vessels.
5. The scale of the change is the point: the other options overstate how much of the protein is altered.
_Source: OpenStax Biology for AP(R) Courses (CC BY 4.0), Ch 3 'Biological Macromolecules', sections 3.1-3.5_
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