Monozygotic (identical) twins most commonly form when a zygote splits during the early:
AMorula stage
BBlastocyst stage
CPronuclear stage
DFetal stage
Answer & Solution
Correct answer: B. Blastocyst stage
1. Monozygotic twins arise when a single zygote divides into two separate embryos during early development.
2. This splitting can technically happen as early as the two-cell stage, but that is not the most common timing.
3. Splitting most commonly occurs during the early blastocyst stage, with roughly 70-100 cells present.
4. Morula stage and Pronuclear stage are both different figures a reader might guess from memory, but neither matches the specific figure given here.
5. Fetal stage is also incorrect for the same reason: it does not match the specific figure given here.
6. This timing determines whether the twins share a placenta (blastocyst-stage split) or have individual placentas (two-cell-stage split).
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 28 "Development and Inheritance", p.1321-1322 §The Zygote_
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