In people with cystic fibrosis, sweat chloride levels are elevated to approximately what multiple of normal?

1. Cystic fibrosis is a hereditary chronic lung disease that also disrupts chloride channel function. 2. One diagnostic clue is abnormal sweat chloride concentration. 3. Sweat chloride in cystic fibrosis patients is two to five times normal levels. 4. 1.5 times understates the true elevation, and 50 times wildly overstates it. 5. 10 to 15 times also overstates the reported multiple, well above the two-to-five-times range. 6. This measurable elevation is why sweat analysis is used diagnostically. 7. So 2 to 5 times is correct. _Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 26 "Fluid, Electrolyte, and Acid-Base Balance", p.1261 §Chloride_