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HER2 is a receptor tyrosine kinase that is permanently activated in a large share of human breast cancers. Roughly what fraction of human breast cancers show this permanent HER2 activation?
A10 percent
B30 percent
C50 percent
D70 percent
Answer & Solution
Correct answer: B. 30 percent
1. HER2 is described as a receptor tyrosine kinase.
2. In 30 percent of human breast cancers, HER2 is permanently activated, resulting in unregulated cell division.
3. Lapatinib inhibits HER2 autophosphorylation and reduces tumor growth by 50 percent, a separate figure from the fraction of cancers affected.
4. 10 percent is not the figure given for permanently activated HER2 in breast cancers.
5. 50 percent is the figure given for tumor growth reduction by Lapatinib, not for cancers with permanent HER2 activation.
6. 70 percent is not the figure given for HER2 activation in breast cancers.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 9 "Cell Communication", section Types of Receptors_
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