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A cell-surface receptor has three main structural regions. Which set correctly names them?
AAn external ligand-binding domain, a nuclear localization signal, and a phosphate group
BAn external ligand-binding domain, a membrane-spanning region, and an intracellular domain
CA cytoplasmic ligand-binding domain, an extracellular tail, and a Golgi-targeting sequence
DA DNA-binding domain, a membrane-spanning region, and a ribosome-binding site
Answer & Solution
Correct answer: B. An external ligand-binding domain, a membrane-spanning region, and an intracellular domain
1. Each cell-surface receptor has three main components.
2. These are an external ligand-binding domain, a hydrophobic membrane-spanning region, and an intracellular domain inside the cell.
3. A DNA-binding domain belongs to internal receptors that act inside the nucleus, not to cell-surface receptors.
4. A nuclear localization signal and a ribosome-binding site are not listed among the three components described for these receptors.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 9 "Cell Communication", section 9.1 Signaling Molecules and Cellular Receptors_
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