alleryStart learning →Blood substitutes under development contain which oxygen carriers?
AHemoglobin-based and perfluorocarbon-based
BAlbumin-based and phospholipid-based ones
CTransferrin-based and ferritin-based ones
DFibrinogen-based and globulin-based ones
Answer & Solution
Correct answer: A. Hemoglobin-based and perfluorocarbon-based
1. The aim of an artificial blood is to carry out the oxygen-carrying function without red blood cells.
2. Removing the cells removes the surface antigens, so incompatibility stops being a concern in the field.
3. Such substitutes normally contain hemoglobin-based and perfluorocarbon-based oxygen carriers.
4. Transferrin and ferritin handle iron rather than oxygen, so neither could do the job.
5. Albumin, fibrinogen and the globulins are plasma proteins with transport, clotting and immune roles, none of which is oxygen carriage.
6. The whole point of the design is to keep the hemoglobin function while discarding the cell that normally carries it.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 18 "The Cardiovascular System: Blood", section 18.6 Blood Typing_
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