alleryStart learning →When is RhoGAM normally administered to an Rh negative mother?
AAt conception and again at twelve weeks
BAt weeks 26 to 28 and just after birth
COnly within 72 hours after the delivery
DAt weeks 12 to 14 and again at term
Answer & Solution
Correct answer: B. At weeks 26 to 28 and just after birth
1. RhoGAM is Rh immune globulin, and its antibodies destroy any fetal Rh positive erythrocytes that cross the placental barrier.
2. Removing those cells prevents the mother from becoming sensitised in the first place.
3. It is given during weeks 26 to 28 of pregnancy, covering exposure late in gestation.
4. A second dose is given within 72 hours following birth, covering the delivery itself, which is the commonest moment of exposure.
5. A post-delivery dose alone would leave the antenatal window uncovered, so the option limiting treatment to 72 hours after birth is incomplete rather than simply wrong.
6. Dosing at conception would be far too early, since fetal cells are not yet crossing.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 18 "The Cardiovascular System: Blood", section 18.6 Blood Typing_
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