A patient carries the A antigen on the erythrocyte membrane. Which antibody circulates in that patient's plasma?
AAnti-A antibody
BAnti-A and anti-B
CAnti-B antibody
DNeither antibody
Answer & Solution
Correct answer: C. Anti-B antibody
1. An antibody attacks what the body reads as nonself.
2. This patient carries the A antigen, so A is self and cannot be attacked.
3. The B antigen is absent from these erythrocytes, so B is nonself.
4. The ABO group is unusual in that the antibody is preformed, without any prior exposure to incompatible blood.
5. A type A individual therefore has preformed anti-B antibodies circulating in the plasma.
6. Anti-A would agglutinate the patient's own cells, which is why that option is self-defeating.
7. Carrying both antibodies belongs to type O and carrying neither belongs to type AB, so each of those options names a different type.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 18 "The Cardiovascular System: Blood", section 18.6 Blood Typing_
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