Why can an incompatible transfusion lead to kidney failure?

1. Hemolysis of the agglutinated erythrocytes releases their hemoglobin into the bloodstream. 2. That free hemoglobin travels to the kidneys, which are responsible for filtering blood. 3. The load released can easily overwhelm the capacity of the kidney to clear it. 4. Kidney failure can therefore develop quickly. 5. The antibodies are directed at the donor red cell antigens, not at kidney tubule cells, so that option misdirects the immune attack. 6. Agglutinated clumps do block small vessels throughout the body, but the renal injury described here is the filtration load rather than arterial occlusion. _Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 18 "The Cardiovascular System: Blood", section 18.6 Blood Typing_