Which vasodilator is released during fibrinolysis to reverse the effects of serotonin and prostaglandins?
ABradykinin
BEndothelin
CHistamine
DAntithrombin
Answer & Solution
Correct answer: A. Bradykinin
1. Serotonin and prostaglandins from the platelets held the vessel constricted during hemostasis.
2. To restore circulation, that constriction must be undone as the clot is degraded.
3. Bradykinin, a vasodilator, is released during fibrinolysis and reverses their effects.
4. The vessel smooth muscle relaxes and flow returns.
5. Endothelin does the opposite, triggering the vascular spasm at the start of hemostasis.
6. Antithrombin is an anticoagulant rather than a vasodilator, so it acts on the cascade and not on vessel calibre.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 18 "The Cardiovascular System: Blood", section 18.5 Hemostasis_
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