alleryStart learning →Why is a matching donor essential for a bone marrow transplant?
ATo keep the donated marrow from clotting
BTo stop the immune system destroying it
CTo match the recipient ABO blood type
DTo raise the recipient hematocrit first
Answer & Solution
Correct answer: B. To stop the immune system destroying it
1. Donor marrow stem cells are infused intravenously and must settle in the recipient marrow.
2. If the recipient immune system reads them as foreign it destroys them, a phenomenon called tissue rejection.
3. Matching the donor is what prevents that rejection.
4. Marrow is not transplanted as a clotting problem and hematocrit is not the gate, so those options miss the mechanism.
5. ABO matching governs red cell transfusion rather than marrow graft acceptance, which makes it the plausible-sounding trap.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 18 "The Cardiovascular System: Blood", section 18.2 Production of the Formed Elements_
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