Which compound made by red cells promotes the dissociation of oxygen from haemoglobin?
ACarbonic anhydrase
BCarbaminohaemoglobin
C2,3-bisphosphoglycerate
DErythropoietin hormone
Answer & Solution
Correct answer: C. 2,3-bisphosphoglycerate
1. Erythrocytes produce 2,3-bisphosphoglycerate as a byproduct of glycolysis.
2. BPG promotes the dissociation of oxygen from haemoglobin.
3. The greater the concentration of BPG, the more readily oxygen dissociates, whatever its partial pressure.
4. So the third option is correct.
5. Carbonic anhydrase catalyses the carbon dioxide and water reaction rather than acting on oxygen binding.
6. Erythropoietin is a kidney hormone that raises red cell production, so it changes carrying capacity rather than the release of oxygen from a given molecule.
_Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 22 "The Respiratory System", section 22.5 Transport of Gases_
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