A rise in tissue temperature has what effect on the oxygen haemoglobin curve?

1. Factors other than partial pressure shift how readily haemoglobin gives up oxygen. 2. A higher temperature promotes haemoglobin and oxygen to dissociate faster. 3. A lower temperature inhibits dissociation. 4. So warming shifts the curve toward unloading, which is a right shift in the usual convention. 5. Highly active tissue releases energy as heat, so this mechanism delivers more oxygen exactly where it is being used. 6. The first option reverses the direction and would starve the hardest working tissue of oxygen. _Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 22 "The Respiratory System", section 22.5 Transport of Gases_