alleryStart learning →Which ribosomal subunit binds the mRNA template, and which one binds the tRNAs?
ASmall binds mRNA, large binds tRNAs
BLarge binds mRNA, small binds tRNAs
CSmall binds both mRNA and the tRNAs
DLarge binds both mRNA and the tRNAs
Answer & Solution
Correct answer: A. Small binds mRNA, large binds tRNAs
1. Ribosomes split into large and small subunits when idle and rejoin as translation begins.
2. The small subunit binds the mRNA template, which is why initiation starts with the small subunit landing on the message.
3. The large subunit sequentially binds the tRNAs, and its three compartments are the A, P and E sites.
4. Putting the mRNA on the large subunit reverses the division of labour and is the trap here.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 15 "Genes and Proteins", section 15.5 Ribosomes and Protein Synthesis_
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