What terminates transcription of a gene read by RNA polymerase I?
AA hairpin that forms within the transcript
BAn 18-nucleotide sequence read by a protein
CA run of G nucleotides on the template
DA release factor entering the polymerase
Answer & Solution
Correct answer: B. An 18-nucleotide sequence read by a protein
1. Unlike RNA polymerase II, both polymerase I and polymerase III need real termination signals.
2. Genes read by RNA polymerase I carry a specific 18-nucleotide sequence.
3. A termination protein recognizes that sequence and ends transcription.
4. Termination by RNA polymerase III instead uses a hairpin, so the hairpin option names the wrong enzyme.
5. A run of G nucleotides on the template is the prokaryotic rho-dependent signal.
6. Release factors act at nonsense codons during translation, so they play no part in transcription.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 15 "Genes and Proteins", section 15.3 Eukaryotic Transcription_
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