Transcription requires the DNA double helix to unwind locally. What is that unwound region called?
AThe transcription bubble
BThe initiation site
CThe replication fork
DThe promoter region
Answer & Solution
Correct answer: A. The transcription bubble
1. Both prokaryotic and eukaryotic transcription need the double helix to open where mRNA is being made.
2. That locally unwound stretch is the transcription bubble.
3. The initiation site is the single +1 nucleotide pair and the promoter is the binding sequence upstream of it, so neither names the opened region.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 15 "Genes and Proteins", section 15.2 Prokaryotic Transcription_
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