allerySemiconservative DNA replication was experimentally demonstrated by
AHershey and Chase
BMeselson and Stahl
CAvery, MacLeod and McCarty
DGriffith
Answer & Solution
Correct answer: B. Meselson and Stahl
1. Meselson and Stahl labelled DNA with heavy ¹⁵N then shifted bacteria to light ¹⁴N medium.
2. Density-gradient centrifugation of progeny DNA showed intermediate density in generation I and a mix of hybrid and light in generation II.
3. This pattern matches the semiconservative replication model.
_Source: Maharashtra Balbharati Std XII Biology, Ch 4 "Molecular Basis of Inheritance" §4.5_
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