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Sickle cell anaemia results from a change in the nucleotide sequence of a single gene. This kind of change is best classified as which type of mutation?
AChromosomal mutation
BEuploidy
CGene or point mutation
DAneuploidy
Answer & Solution
Correct answer: C. Gene or point mutation
1. Mutations are of two main kinds: chromosomal and gene mutations.
2. A change in the nucleotide sequence of a single gene is a gene or point mutation.
3. Sickle cell anaemia is caused by such a single-gene change altering the haemoglobin protein.
4. Chromosomal mutation changes the structure or number of chromosomes, not a single gene, which rules out option A.
5. So this is a gene or point mutation, option C.
_Source: Samacheer Kalvi (TN SCERT) Class 10 Science, Unit 18 Genetics "Gene or point mutation", p.277_
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