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The **30-nm chromatin fibre** in eukaryotic chromosomes arises by:
ADirect condensation of DNA without histones
BCoiling of the 10-nm 'beads-on-string' nucleosome fibre into a solenoid (≈6 nucleosomes/turn)
CRemoval of all histones
DSplicing of introns
Answer & Solution
Correct answer: B. Coiling of the 10-nm 'beads-on-string' nucleosome fibre into a solenoid (≈6 nucleosomes/turn)
10-nm fibre = nucleosomes on string. ~6 nucleosomes coil into a solenoid ≈30 nm diameter — the second packaging level. Further looping and supercoiling form the chromatid (assisted by non-histone chromosomal proteins), reaching the highly condensed metaphase chromosome.
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