alleryIn the TCA cycle, CO2 is released at which step pair?
AIsocitrate to alpha-KG and alpha-KG to succinyl CoA
BCitrate to isocitrate and succinate to fumarate
CFumarate to malate and malate to OAA
DPyruvate to acetyl CoA and OAA to citrate
Answer & Solution
Correct answer: A. Isocitrate to alpha-KG and alpha-KG to succinyl CoA
Two CO2 are released per turn of the TCA cycle.
Isocitrate dehydrogenase makes alpha-KG + CO2 + NADH
alpha-KG dehydrogenase makes succinyl CoA + CO2 + NADH.
(Pyruvate to acetyl CoA is OUTSIDE the cycle.)
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