Cisplatin, $[Pt(NH_3)_2Cl_2]$, is a **square planar** complex used as an anticancer drug. The trans-isomer:
- Has the same anticancer activity
- Is physiologically inactive
- Is more potent
- Cannot exist for square planar geometry
Show answer and solution
Correct answer: B. Is physiologically inactive
Only the **cis** isomer is biologically active (binds adjacent N₇ of two guanine bases in DNA).
trans-Pt(NH₃)₂Cl₂ is inactive.
Geometry isomerism matters enormously for drug action.