Sickle-cell anaemia is an example of which type of inheritance?
- Sex-linked dominant
- Sex-linked recessive
- Autosomal recessive (also a pleiotropic gene)
- Y-linked
Show answer and solution
Correct answer: C. Autosomal recessive (also a pleiotropic gene)
Sickle-cell anaemia is caused by a recessive autosomal allele (Hb^s).
Homozygotes (Hb^s Hb^s) develop full disease and usually die early
heterozygotes (Hb^A Hb^s) are carriers with mild anaemia only under low O₂.
It also shows **pleiotropy** — one gene causes multiple effects (anaemia, organ damage, malaria resistance).