allerySickle-cell anaemia is an example of which type of inheritance?
ASex-linked dominant
BSex-linked recessive
CAutosomal recessive (also a pleiotropic gene)
DY-linked
Answer & Solution
Correct answer: C. Autosomal recessive (also a pleiotropic gene)
Sickle-cell anaemia is caused by a recessive autosomal allele (Hb^s).
Homozygotes (Hb^s Hb^s) develop full disease and usually die early
heterozygotes (Hb^A Hb^s) are carriers with mild anaemia only under low O₂.
It also shows **pleiotropy** — one gene causes multiple effects (anaemia, organ damage, malaria resistance).
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