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D-glucose and D-mannose are epimers. Differ in configuration at:

AC1
BAll centers
CC2 only (epimers differ at exactly one chiral center)
DC5
Answer & Solution
Correct answer: C. C2 only (epimers differ at exactly one chiral center)
Epimers: stereoisomers differing at exactly one chiral center. D-glucose and D-mannose differ only at C2 (one is R, other S). D-glucose and D-galactose are C4 epimers. Important in biosynthesis (epimerases interconvert).
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