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Because of that liver step, oral medicines are usually less:

ABiochemical
BBiomedical
CBioavailable
DBiodegradable
Answer & Solution
Correct answer: C. Bioavailable
1. Part of the dose never reaches circulation. 2. Less active drug arrives in blood. 3. So they are less bioavailable. _Source: OpenStax Pharmacology for Nurses, Chapter 2, Drug Administration and Pharmacokinetics._
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