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The enzyme that relieves supercoiling ahead of the replication fork is:

ATransaminase
BTranscriptase
CTranslocase
DTopoisomerase
Answer & Solution
Correct answer: D. Topoisomerase
1. Unwinding the helix twists the DNA ahead of it. 2. One enzyme cuts and rejoins to release that strain. 3. It is topoisomerase. _Source: OpenStax Biology 2e, Chapter 14, DNA Structure and Function._
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