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A spontaneous mutation altering the shape of a drug's binding site causes resistance through target:

AChange
BCharge
CChain
DChart
Answer & Solution
Correct answer: A. Change
1. Antimicrobials bind very specific structures. 2. Altering the structure prevents binding. 3. So a target change confers resistance. _Source: OpenStax Microbiology, Chapter 14, Antimicrobial Drugs._
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