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The chill and recurring high fever of malaria are caused by the toxic substance:

AHaemozoin
BHistamine
CSerotonin
DInterferon
Answer & Solution
Correct answer: A. Haemozoin
1. It is released when red blood cells rupture. 2. The toxin is haemozoin. 3. Fever recurs every three to four days. _Source: syllabus Biology, Chapter 8, Human Health and Disease._
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