Sickle cell anaemia differs from haemophilia in that its gene is carried on:
Athe X chromosome, so it is sex-linked
Bthe Y chromosome, so only males inherit it
Ca plasmid, so it is inherited maternally
Dan autosome, so it is not sex-linked
Answer & Solution
Correct answer: D. an autosome, so it is not sex-linked
1. Sickle cell anaemia is controlled by a recessive gene like haemophilia.
2. But that gene sits on an autosome, one of the chromosomes that is not a sex chromosome.
3. So the condition appears with equal frequency in males and females.
4. A genetic cross for it uses ordinary allele letters, with no X or Y attached.
5. Using X and Y chromosomes to represent the sickle cell alleles was the single most common recorded error on this question.
_Source: NECTA ACSEE 2023 Biology 133/2, Question 4: Genetics_
Keep practising Genetics
Browse all Genetics questions for ACSEE (Form 6), or explore more Biology topics.