The major component of connective tissue matrix is the:

1. Protein fibres crisscross it. 2. It can be fluid or mineralised. 3. The major component of the matrix is a ground substance often crisscrossed by protein fibers. 4. So the answer is ground substance. _Source: OpenStax 'Anatomy and Physiology 2e', Ch 4 'The Tissue Level of Organization'_