Leukemia accounted for 117,033 years of potential life lost among 252,755,000 people under age 65. What is the YPLL rate per 1,000?

1. A YPLL rate divides total years lost by the population below the end-point age. 2. The denominator is therefore the 252,755,000 people under 65, not the whole population. 3. 117,033 divided by 252,755,000 equals 0.000463. 4. Multiplying by 1,000 gives 0.463, which rounds to 0.5 YPLL per 1,000 population under age 65. 5. 4.6 applies a multiplier of 10,000 and 46.3 applies 100,000, so both overstate the rate. 6. 0.4 per 1,000 is the trap: it puts the whole population of 288,357,000 in the denominator instead of the 252,755,000 under age 65. _Source: CDC Principles of Epidemiology in Public Health Practice (3rd ed., US federal, public domain), Lesson 3 "Measures of Risk", section Method for calculating YPLL from a frequency_