Home › NCK Licensing Exam (Nursing) › Microbiology › Bacteriology › Many antibiotics hit bacterial wall construction…
Many antibiotics hit bacterial wall construction because their structure mimics which molecules?
AL-amino acids found in most proteins
BPolysaccharide chains of the capsule
CD-amino acids of the wall peptides
DPhytanyl side chains of the membrane
Answer & Solution
Correct answer: C. D-amino acids of the wall peptides
1. Peptidoglycan chains are cross-linked by peptides that carry both L- and D-amino acids.
2. D-glutamic acid and D-alanine are two of those unusual D-amino acids.
3. Ordinary proteins are built almost entirely from L-amino acids, so D-forms are a bacteria-specific target.
4. Many antibiotics therefore work by mimicking D-amino acids, acting on wall development.
5. Mimicking L-amino acids would interfere with the patient's own proteins, so that is the trap in the first option.
6. Capsule polysaccharides and archaeal phytanyl chains are not the target of this class of drugs.
_Source: OpenStax Biology (1st ed., CC BY 4.0), Ch 22 "Prokaryotes: Bacteria and Archaea", section 22.2 Structure of Prokaryotes_
Related questions
Which structure lets some soil bacteria survive heat and drought until conditions improve?Commensal bacteria on the skin and in the gut benefit their human host in which way?How do bacteria such as Pseudomonas aeruginosa help clear mercury pollution?Why must a legume root nodule stay free of oxygen?Which organisms carry out biological nitrogen fixation?Roughly what proportion of recently emerging human infectious diseases are zoonoses?High doses of antibiotics can let which organism overgrow the gut and cause chronic diarrhA disease that is constantly present at low incidence in a population is described as what