Which sign is not one of the four characteristics of inflammation?

1. Inflammation is the hallmark of the innate immune response and follows tissue damage of any kind. 2. Its four characteristics are heat, redness, pain and swelling, with loss of function sometimes mentioned as a fifth. 3. Heat and redness come from the increased blood flow of vasodilation, and swelling comes from increased vascular permeability. 4. Cold appears nowhere among those characteristics, so it is the odd sign out. _Source: OpenStax Anatomy and Physiology (CC BY 4.0), Ch 21 "The Lymphatic and Immune System", section 21.2 Barrier Defenses and the Innate Immune Response_